Ket Hing Chong
Academic Profile
Education
Jan 2019 – Feb 2020: Postdoctoral Research Fellow at PrescottLab of The Hospital for Sick Children Canada and
Department of Physiology, University of Toronto
Mentor: Associate Professor Steve A Prescott
May 2015 – Jan 2017 & Mar 2017 - May 2018: Postdoctoral Research Fellow, Nanyang Technological University (NTU)
Singapore
Mentor: Associate Professor Jie Zheng
July 2010 – December 2014: Doctor of Philosophy in Computational Systems Biology, Lincoln University New Zealand
Research co-supervised by Professor Sandhya Samarasinghe and Professor Don Kulasiri.
Thesis title: “Mathematical Modelling of the core regulatory feedback mechanisms of p53 protein that decide cell fate” [PDF]
P53, a tumour suppressor, is a key node in the network that integrates various stress signals in DNA damage response. My thesis focus is on mathematical models of p53 system dynamics in response to DNA damage in the form of double-strand breaks, which include non-stressed and stressed conditions, and activation of apoptotic switch under severe damage. The construction of delay differential equations are based on the core regulators that control p53 activation. The mathematical models were converted into computer models through software (XPPAUT and MATLAB) for simulations and analyses. The models give novel theoretical insights into how p53 dynamics control its function as a guardian of the genome in maintaining the integrity of the genome.
January 2003: Master of Science (Information Technology), Universiti Putra Malaysia.
July 1997: Bachelor of Science (Major Mathematics), Universiti Putra Malaysia.
Jan 2019 – Feb 2020: Postdoctoral Research Fellow at PrescottLab of The Hospital for Sick Children Canada and
Department of Physiology, University of Toronto
Mentor: Associate Professor Steve A Prescott
May 2015 – Jan 2017 & Mar 2017 - May 2018: Postdoctoral Research Fellow, Nanyang Technological University (NTU)
Singapore
Mentor: Associate Professor Jie Zheng
July 2010 – December 2014: Doctor of Philosophy in Computational Systems Biology, Lincoln University New Zealand
Research co-supervised by Professor Sandhya Samarasinghe and Professor Don Kulasiri.
Thesis title: “Mathematical Modelling of the core regulatory feedback mechanisms of p53 protein that decide cell fate” [PDF]
P53, a tumour suppressor, is a key node in the network that integrates various stress signals in DNA damage response. My thesis focus is on mathematical models of p53 system dynamics in response to DNA damage in the form of double-strand breaks, which include non-stressed and stressed conditions, and activation of apoptotic switch under severe damage. The construction of delay differential equations are based on the core regulators that control p53 activation. The mathematical models were converted into computer models through software (XPPAUT and MATLAB) for simulations and analyses. The models give novel theoretical insights into how p53 dynamics control its function as a guardian of the genome in maintaining the integrity of the genome.
January 2003: Master of Science (Information Technology), Universiti Putra Malaysia.
July 1997: Bachelor of Science (Major Mathematics), Universiti Putra Malaysia.
Research Interests
p53 system dynamics, mathematical modelling, ageing, cancer research, neuron homeostatic regulation and systems biology.